Determination of histamine PC20. Comparison of linear and logarithmic interpolation.
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چکیده
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منابع مشابه
Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine.
The value of determining the slope of the histamine dose-response curve, in addition to the histamine provocation concentration producing a 20% reduction in FEV1 (PC20-FEV1), was assessed by analysis of histamine dose-response curves in 40 patients selected as having a wide range of increased non-specific bronchial responsiveness to inhaled histamine. The histamine dose-response curves were fou...
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The relation between airway responsiveness to propranolol and histamine was studied in 32 asthmatic children. Propranolol and histamine were given by nebuliser to a maximum dose of 16 mg/ml and 32 mg/ml respectively and the response was measured as the provocative concentration of agonist causing a 20% fall in FEV1 (PC20). A PC20 histamine value of less than 32 mg/ml was obtained in 24 of the 3...
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BACKGROUND It has recently been reported that acetaldehyde induces bronchoconstriction indirectly via histamine release. However, no study has been performed to assess whether acetaldehyde worsens bronchial responsiveness in asthmatic subjects so this hypothesis was tested. METHODS Methacholine provocation was performed on three occasions: (1) after pretreatment with oral placebo and inhaled ...
متن کاملMeasurement of responsiveness to inhaled histamine using FEV1: comparison of PC20 and threshold.
Two methods of interpreting histamine inhalation dose-response curves were compared in 27 normal and 41 asthmatic subjects. The histamine provocation concentration producing a 20% fall (PC20) in forced expiratory volume in one second (FEV1) was calculated on the basis of the lowest FEV1 after inhalation of saline and the lowest value after inhalation of histamine. The histamine threshold was de...
متن کاملPerception scoring of induced bronchoconstriction as an index of awareness of asthma symptoms.
Perception of asthma symptoms shows a wide interindividual variability. Poor perception of airflow obstruction may lead to undertreatment of asthma. We reviewed the possibility of using a simple test to detect poor perceivers of bronchoconstriction as part of the investigation of asthmat. We studied 150 consecutive subjects referred for assessment of airway responsiveness. All had a histamine P...
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عنوان ژورنال:
- Chest
دوره 84 4 شماره
صفحات -
تاریخ انتشار 1983